The Health and Well-being domain comprises the many needs and activities of the family related to medical, psychological, and spiritual matters impacting individual and family functioning in the context of wealth and the family enterprise. Examples include the impact of dementia or disability in a family elder or leader, biological or learning factors (e.g., neurocognitive issues) affecting preparation for wealth roles or responsibilities, overseas illness necessitating emergency or concierge medical services, substance abuse by a family enterprise member, or sudden illness impacting a family transition or leadership plan. Professionals working in this domain must understand issues of wealth, confidentiality, and coordination of care management that account for unique factors such as trusts or family enterprise roles. 

The Health and Well-being domain is a component of the Cultivation of Family Capital cluster in the Ten Domains of Family Wealth model of The UHNW Institute.